At least 15 people received injures in the collision, rescue sources informed.
The passenger coach was heading to Karachi from Dera Ghazi Khan when this incident happened, a sight which is painful for the eye witnesses.
The rescue officials said that injured people had been shifted to nearby hospital after the incident.
The premier, Nawaz Sharif, expressed grief over the incident and extended his words for the grieved families.
Reckless driving on the super highways has become a routine of buses and trucks drivers who never bother to care about other vehicles in an effort to reach their destination at the earliest.